PET and SPECT standards and their precursors

PharmaSynth produces ligands used in the study of biochemical changes in human brain related to:
Degenerative processes
Behavioral changes
Drug abuse
Addiction
Our products cover the most important systems and other target systems.

Products based on applications

Acetylcholinesterase

MP4A HCl (AMP HCl)

Reference standard

[58931-63-8]

PA HCl

Precursor

[94886-04-1]

Adenosine receptor A2a

Desmethyl-SCH442416

Precursor for PET tracer [11C]SCH442416

[188112-92-7]

Desmethyl-TMSX

Precursor for PET tracer [11C]TMSX

[147700-34-3]

SCH442416

Reference standard for PET tracer [11C]SCH442416

[316173-57-6]

TMSX

Reference standard for PET tracer [11C]TMSX

[51389-37-8]

Amyloid plaque deposit

6-MOMO-BTA-0

Precursor

[566170-03-4]

6-MeO-BTA-0

Reference standard

[43036-17-5]

6-OH-BTA-1

Reference standard

[566169-93-5]

6-OH-BTA-0

Precursor

[178804-18-7]

Cannabinoid receptor 1

FMePPEP

Reference standard

[1059188-86-1]

MePPEP

Reference standard

[1059188-74-7]

PPEP

Precursor

[1059188-84-9]

Dopamine receptor D1

Desmethyl-NNC-112

Reference standard for PET tracer [11C]NNC 112

[221132-62-3]

Desmethyl-SCH-23390 (SCH-24518) SCH-24518

Precursor for PET tracer [11C]SCH-23390

[106648-57-1]

(S)-Desmethyl-SCH-23390 (S)-SCH-24518

Precursor for PET tracer [11C]SCH-23390 (S)-enantiomer

[135556-21-7]

NNC-112

Reference standard for PET tracer [11C]NNC 112

[125341-24-4]

SCH-23390

Reference standard for PET tracer [11C]SCH23390

[87075-17-0]

Dopamine receptor D2/D3

Bu3Sn-Epidepride

Precursor

[135382-47-7]

Desmethylraclopride

Precursor for PET tracer [13C]-Raclopride

[119670-11-0]

Desmethylraclopride triflate

Precursor for PET tracer [13C]-Raclopride

[119670-11-0 (free base)]

Epidepride HCl

Reference standard

[253453-57-3]

FLB 604 nor-FLB 457

Precursor for PET tracer [11C]FLB 457

[128600-22-6]

FLB 457 HBr

Reference standard for PET tracer [11C]FLB 457

[128600-22-6]

Fallypride

Reference standard

[166173-78-0]

MCL-556

Precursor for PET tracer [18F]MCL-524

[NA]

MCL-524 HCl

Reference standard for PET tracer [18F]MCL-524

[1340476-46-1]

MNPA HCl

Reference standard for PET tracer [11C]MNPA

[126874-83-7]

N-Methylspiperone

Reference standard

[87539-19-3 (HCl salt)]

Raclopride

Reference standard for PET tracer [13C]-Raclopride

[84225-95-6]

Raclopride tartrate for PET tracer [13C]-Raclopride

Reference standard

[98185-20-7]

Spiperone

Precursor

[749-02-0]

TNPA HCl

Precursor for PET tracer [11C]MNPA

[1114452-57-1]

TNPA-acetonide

Precursor for PET tracer [11C]MNPA

[1094076-46-6]

TNPA-methylenedioxy HCl

Precursor for PET tracer [11C]MNPA

[126874-88-2]

Tosylfallypride

Precursor

[166173-74-6]

Dopamine transporter

β−CFΤ

Reference standard for PET tracer [11C]β-CFT

[50370-56-4]

β−CFΤ−acid

Precursor for PET tracer [11C]β-CFT

[53898-64-9]

β−CΙΤ beta-CIT

Reference standard

[135416-43-2]

Desmethyl-PE2I

Precursor for PET tracer [11C]-PE2I

[311351-26-5]

FE-PE2I

Reference standard

[949091-68-3]

PE2I

Reference standard for PET tracer [11C]-PE2I

[188680-71-9]

Bu3Sn-PE2I

Precursor for SPECT tracer [123-I]-PE2I

[188680-65-1]

TMS-CT

Precursor

[158111-10-5]

Tosylethyl-PE2I

Precursor

[1391711-43-5]

nor-β-CFT

Precursor for PET tracer [11C]β-CFT

[127648-30-0]

nor-β-CIT nor-beta-CIT

Precursor for PET tracer [11C]β-CIT

[136794-87-1]

p-Me-β-CPT

Reference standard

[130342-81-3]

p-Me-β-CPT-acid

Precursor

[141807-59-2]

p-Me-nor-β-CPT

Precursor

[188680-62-8]

Dopaminergic system

4-O-Pivaloyl-L-DOPA HCl

Precursor

[122551-95-5]

Tri-Boc-6-Me3Sn-L-DOPA methyl ester

Precursor

[857502-21-7]

Histamine receptor H1

Desmethyldoxepin

Precursor for histamine H1 receptor radiotracer [11C] doxepin

[2887-91-4 (HCl salt)]

Doxepin hydrochloride

Reference standard for histamine H1 receptor radiotracer [11C] doxepin

[1668-19-5]

Imidazoline 2 binding site

BU99008

Reference standard

[108796-88-9]

BU99007

Precursor

[1415702-13-4]

Monoamine oxidase B

D2-(R)-Deprenyl HCl

Reference standard for PET tracer [11C]D2-(R)-Deprenyl

[1254320-90-5]

D2-(R)-Desmethyldeprenyl HCl

Precursor for PET tracer [11C]D2-(R)-Deprenyl

[235792-98-0 (free base)]

(R)-Deprenyl HCl

Reference standard for PET tracer (R)-(−)-[11C]Deprenyl

[14611-52-0]

(R)-Desmethyldeprenyl HCl

Precursor for PET tracer [11C]D2-(R)-Deprenyl

[115586-38-4]

(S)-Desmethyldeprenyl HCl

Precursor for PET tracer (S)-(+)-[11C]Deprenyl

[403646-91-3]

Neurokinin 1 receptor

FESPARQ FE-SPA-RQ

Reference standard for PET NK1 receptor radiotracer [18F]FESPARQ

[677000-31-6]

F-SPARQ F-SPA-RQ

Reference standard for NK1 receptor radiotracer [18F]F-SPARQ

[262598-96-9]

GR 205171

Reference standard for PET tracer [11C]GR 205171

[168266-90-8]

SPARQ (Desmethyl-GR 205171)

Precursor for PET NK1 receptor radiotracers [11C]GR 205171, [18F]F-SPARQ and [18F]FESPARQ

[180574-25-8]

Nicotinic acetylcholine receptor

(S)-(-)-Nicotine

Reference standard

[54-11-5]

(S)-(-)-Nornicotine bitartrate

Precursor

[494-97-3 (free base)]

Norepinephrine transporter

(S,S)-FD2MeNER TFA

Reference standard for PET tracer [18F]FD2MeNER

[NA]

(S,S)-MeNER

Reference standard for PET tracer (S,S)-[11C]MeNER

[105018-14-2]

(S,S)-NER Norethylreboxetine

Precursor for PET tracers (S,S)-[11C]MeNER and [18F]FD2MeNER

[252570-31-3]

Phosphodiesterase 4

(R)-(-)-Desmethylrolipram

Precursor

[347148-59-8]

(R)-(-)-Rolipram

Reference standard

[85416-75-7]

Serotonin receptor 1A

WAY 100634

Precursor for PET tracer [carbonyl-11C]WAY-100635

[155204-28-7]

WAY 100635 oxalate

Reference standard Standard for…

[146715-97-8 (free base)]

Serotonin receptor 1B

AZ10419369

Reference standard for PET tracer [11C]AZ10419369

[442548-93-8]

N-Desmethyl-AZ10419369

Precursor for PET tracer [11C]AZ10419369

[947239-77-2]

Serotonin receptor 2A

Altanserine HCl

Reference standard

[76330-71-7]

CIMBI-36 HCl

Reference standard

[1026511-90-9 (free base)]

MDL 100907

Reference standard

[139290-65-6]

MDL 105725

Precursor

[189192-18-5]

N-Boc-Desmethyl-CIMBI-36

Precursor

[1404305-57-2]

Nitroaltanserine

Precursor

[139418-53-4]

Nitrosetoperone

Precursor

[113981-16-1]

Setoperone

Reference standard

[86487-64-1]

Serotonin transporter

ADAM

Reference standard for SPECT tracer [123-I]ADAM

[305352-10-7]

DASB

Reference standard for PET tracer [11C]DASB

[627490-01-1]

Desmethyl-DASB MASB

Precursor for PET tracer [11C]DASB

[296774-10-2]

Desmethyl-MADAM

Precursor for PET tracer [11C]MADAM

[412015-27-1]

MADAM

Reference standard for PET tracer [11C]MADAM

[411208-45-2]

Tributyltin-ADAM

Precursor for SPECT tracer [123-I]ADAM

[305352-07-2]

Synaptic vesicle glycoprotein 2A

BF3-Dm-UCB-J

Precursor for PET tracer [11C]UCB-J

[NA]

UCB-J

Reference standard for PET tracer [11C]UCB-J

[2242957-52-2 (1604786-87-9)]

Synaptic vesicle glycoprotein 2A (SV2A)

3-Br-UCB-J

Precursor for PET tracer [18F]UCB-J

[NA]

3-Me3Sn-UCB-J

Precursor for PET tracer [18F]UCB-J (* see remarks)

[NA]

Me3Sn-SDM-2

Precursor

[NA]

Me3Sn-SDM-8 (SynVesT-1 trimethylstannyl precursor)

Precursor for [18]F-SDM-8 ([18]F-SynVesT-1)

[2289636-79-7]

SDM-8 (SynVesT-1)

Reference standard

[2242777-37-1]

Synaptic vesicular amine transporter

(+)-DTBZ

Reference standard

[85081-18-1]

(+)-FCD2CD2-DTBZ

Reference standard

[NA]

(+)-FE-DTBZ

Reference standard

[937245-41-5]

(+)-9-O-Desmethyl-DTBZ

Precursor

[1065193-59-0]

Translocator protein

Bromo-NNC13-8241

Precursor

[106937-64-8]

DPA-713

Reference standard

[386297-97-8]

DPA-714

Reference standard for PET tracer [18F]DPA-714

[958233-07-3]

Desmethyl-DPA-713

Precursor

[868072-17-7]

(R)-Desmethyl-PK11195

Precursor for PET tracer [11C] (R)-PK11195

[157809-85-3]

(S)-Desmethyl-PK11195

Precursor for PET tracer [11C] (S)-PK11195

[157809-86-4]

Desmethylemapunil

Precursor

[226953-50-0]

Desmethylflumazenil

Precursor for PET tracer [11C]flumazenil

[79089-72-8]

ER176

Reference standard for PET tracer [11C]ER176

[1373887-29-6]

Desmethyl-ER176

Precursor for PET tracer [11C]ER176

[1373887-55-8]

Emapunil

Reference standard

[226954-04-7]

Flumazenil

Reference standard for PET tracers [18F]flumazenil and [11C]flumazenil

[78755-81-4]

Me3Sn-NNC13-8241

Precursor

[178403-07-1]

NNC13-8241

Reference standard

[1027662-23-2]

Nitroflumazenil

Precursor for PET tracer [18F]flumazenil

[84377-97-9]

O-Desmethyl-PBR28

Precursor

[1005325-42-7]

PBR28

Reference standard

[253307-72-1]

(R)-PK11195

Reference standard for PET tracer [11C] (R)-PK11195

[85340-56-3]

RO-15 4513

Reference standard

[91917-65-6]

RO-44 3902

Precursor

[143188-51-6]

Tosylate-DPA-714

Precursor for PET tracer [18F]DPA-714

[958233-17-5]

μ−Opioid receptor

Carfentanil oxalate

Reference standard

[61086-44-0]

Desmethylcarfentanil sodium salt

Precursor

[98598-82-4]

Purity
All of our products stand out due to the high performance demonstrated in applications. The chemical purity is always higher than 95%, usually higher than 98%.
GMP
PharmaSynth follows the GMP production guidelines ensuring a validated manufacturing process that involves qualified personnel and premises that suit the operations to be carried out.
Test labeled
We provide an optimization of labeling, as our regular precursor batches are test labeled in Karolinska Institute. The specific activity is usually higher than 10 000 Ci/mmol in 11C labeling (the best achieved is desmethyl-raclopride 52000 Ci/mmol).
Contact
For more information regarding products and services specifications please contact our chief chemist, Olavi Loog at olavi@pharmasynth.ee or our chief scientific officer Hans Christiaans at hans.christiaans@pharmasynth.ee.