PET and SPECT standards and their precursors

PharmaSynth produces ligands used in the study of biochemical changes in human brain related to:
Degenerative processes
Behavioral changes
Drug abuse
Addiction
Our products cover the most important systems and other target systems.

Products based on applications

Adenosine receptor A2a

Desmethyl-SCH442416

Precursor for PET tracer [11C]SCH442416

[188112-92-7]

Desmethyl-TMSX

Precursor for PET tracer [11C]TMSX

[147700-34-3]

SCH442416

Reference standard for PET tracer [11C]SCH442416

[316173-57-6]

TMSX

Reference standard for PET tracer [11C]TMSX

[51389-37-8]

Amyloid plaque deposit

6-MOMO-BTA-0

Precursor for PET tracer [11C]6-OH-BTA-1

[566170-03-4]

6-MeO-BTA-0

Reference standard for PET tracer [11C]6-MeO-BTA-0

[43036-17-5]

6-OH-BTA-1

Reference standard for PET tracer [11C]6-OH-BTA-1

[566169-93-5]

6-OH-BTA-0

Precursor for PET tracer [11C]6-OH-BTA-1

[178804-18-7]

Cannabinoid receptor 1

FMePPEP

Reference standard for PET tracer [18F]FMePPEP

[1059188-86-1]

MePPEP

Reference standard for PET tracer [11C]MePPEP

[1059188-74-7]

PPEP

Precursor for PET tracer [11C]MePPEP or [11C]FMePPEP

[1059188-84-9]

Dopamine receptor D1

Desmethyl-NNC-112

Reference standard for PET tracer [11C]NNC 112

[221132-62-3]

Desmethyl-SCH-23390 SCH-24518

Precursor for PET tracer [11C]SCH-23390

[106648-57-1]

(S)-Desmethyl-SCH-23390 (S)-SCH-24518

Precursor for PET tracer [11C]SCH-23390 (S)-enantiomer

[135556-21-7]

NNC-112

Reference standard for PET tracer [11C]NNC 112

[125341-24-4]

SCH-23390 maleate

Reference standard for PET tracer [11C]SCH23390

[87075-17-0]

Dopamine receptor D2/D3

Bu3Sn-Epidepride

Precursor for SPECT tracer [123I]epidepride

[135382-47-7]

Desmethylraclopride

Precursor for PET tracer [11C]Raclopride

[119670-11-0]

Desmethylraclopride triflate

Precursor for PET tracer [11C]-Raclopride

[119670-11-0 (free base)]

Epidepride HCl

Reference standard for SPECT tracer [123I]epidepride

[253453-57-3]

FLB 604 nor-FLB 457

Precursor for PET tracer [11C]FLB 457

[128600-22-6]

FLB 457 hydrobromide

Reference standard for PET tracer [11C]FLB 457

[128600-22-6]

Fallypride

Reference standard for PET tracer [18F]fallypride

[166173-78-0]

MCL-556

Precursor for PET tracer [18F]MCL-524

[NA]

MCL-524 hydrochloride

Reference standard for PET tracer [18F]MCL-524

[1340476-46-1]

MNPA hydrochloride

Reference standard for PET tracer [11C]MNPA

[126874-83-7]

N-Methylspiperone NMSP

Reference standard for PET tracer [11C]N-Methylspiperone, [11C]NMSP

[87539-19-3]

Raclopride

Reference standard for PET tracer [11C]Raclopride

[84225-95-6]

Raclopride tartrate

Reference standard for PET tracer [11C]raclopride

[98185-20-7]

Spiperone

Precursor for PET tracer [11C]N-methylspiperone

[749-02-0]

TNPA hydrochloride

Precursor for PET tracer [11C]MNPA

[1114452-57-1]

TNPA-acetonide

Precursor for PET tracer [11C]MNPA

[1094076-46-6]

TNPA-methylenedioxy hydrochloride

Precursor for PET tracer [11C]MNPA

[126874-88-2]

Tosylfallypride

Precursor

[166173-74-6]

Dopamine transporter

β−CFΤ beta-CFT

Reference standard for PET tracer [11C]β−CFΤ

[50370-56-4]

β−CFΤ−acid

Precursor for PET tracer [11C]β-CFT

[53898-64-9]

β−CΙΤ beta-CIT, RTI-55

Reference standard for PET tracer [11C]β−CΙΤ or [123I]β−CΙΤ

[135416-43-2]

Desmethyl-PE2I

Precursor for PET tracer [11C]-PE2I

[311351-26-5]

FE-PE2I

Reference standard for PET tracer [18F]FE-PE2I

[949091-68-3]

PE2I

Reference standard for PET tracer [11C]PE2I

[188680-71-9]

Bu3Sn-PE2I

Precursor for SPECT tracer [123I]PE2I

[188680-65-1]

TMS-CT

Precursor for PET tracer [123I]β-CIT

[158111-10-5]

Tosylethyl-PE2I

Precursor

[1391711-43-5]

nor-β-CFT

Precursor for PET tracer [11C]β-CFT

[127648-30-0]

nor-β-CIT nor-beta-CIT

Precursor for PET tracer [11C]β-CIT

[136794-87-1]

p-Me-β-CPT

Reference standard

[130342-81-3]

p-Me-β-CPT-acid

Precursor

[141807-59-2]

p-Me-nor-β-CPT

Precursor

[188680-62-8]

Dopaminergic system

4-O-Pivaloyl-L-DOPA hydrochloride

Precursor for PET tracer [18F]6-fluoro-L-DOPA

[122551-95-5]

Tri-Boc-6-Me3Sn-L-DOPA methyl ester

Precursor

[857502-21-7]

GABA receptor

Desmethylflumazenil Norflumazenil

Precursor for PET tracer [11C]flumazenil

[79089-72-8]

Flumazenil Flumazepil

Reference standard for PET tracers [18F]flumazenil and [11C]flumazenil

[78755-81-4]

Nitroflumazenil

Precursor for PET tracer [18F]flumazenil

[84377-97-9]

Histamine receptor H1

Desmethyldoxepin Nordoxepin

Precursor for PET tracer [11C]doxepin

[2887-91-4 (HCl salt)]

Doxepin hydrochloride

Reference standard for PET tracer [11C]doxepin

[1668-19-5]

Imidazoline 2 binding site

BU99007

Precursor for the PET tracer [11C]BU99008

[1415702-13-4]

BU99008

Reference standard for PET tracer [11C]BU99008

[108796-88-9]

Monoamine oxidase B

D2-(R)-Deprenyl hydrochloride

Reference standard for PET tracer [11C]D2-(R)-Deprenyl

[1254320-90-5]

D2-(R)-Desmethyldeprenyl hydrochloride

Precursor for PET tracer [11C]D2-(R)-Deprenyl

[235792-98-0 (free base)]

(R)-Deprenyl HCl L-Deprenyl HCl

Reference standard for PET tracer (R)-(−)-[11C]Deprenyl

[14611-52-0]

(R)-Desmethyldeprenyl HCl L-Nordeprenyl HCl

Precursor for PET tracer [11C](R)-(−)-Deprenyl

[115586-38-4]

(S)-Desmethyldeprenyl HCl D-Deprenyl HCl

Precursor for PET tracer [11C](S)-(+)-Deprenyl

[403646-91-3]

(R)-Desmethyldeprenyl dihydrogen sulphate

Precursor for PET tracer [11C](R)-deprenyl

(S)-Deprenyl hydrochloride

Reference standard for PET tracer [11C](S)-deprenyl

[4528-52-3]

Neurokinin 1 receptor

FESPARQ FE-SPA-RQ

Reference standard for PET NK1 receptor radiotracer [18F]FESPARQ

[677000-31-6]

F-SPARQ F-SPA-RQ

Reference standard for PET tracer [18F]F-SPARQ

[262598-96-9]

GR 205171

Reference standard for PET tracer [11C]GR 205171

[168266-90-8]

SPARQ (Desmethyl-GR 205171)

Precursor for PET tracers  [11C]GR 205171, [18F]F-SPARQ and [18F]FESPARQ

[180574-25-8]

Nicotinic acetylcholine receptor

(S)-(-)-Nicotine

Reference standard for the PET tracer [11C](S)-(-)-nicotine

[54-11-5]

(S)-(-)-Nornicotine bitartrate

Precursor for PET tracer [11C](S)-(-)-nicotine

[494-97-3 (free base)]

Norepinephrine transporter

(S,S)-FD2MeNER TFA

Reference standard for PET tracer [18F]FD2MeNER

[NA]

(S,S)-MeNER

Reference standard for PET tracer (S,S)-[11C]MeNER

[105018-14-2]

(S,S)-NER Norethylreboxetine

Precursor for PET tracers (S,S)-[11C]MeNER and [18F]FD2MeNER

[252570-31-3]

Phosphodiesterase 4

(R)-(-)-Desmethylrolipram

Precursor for PET tracer [11C]rolipram

[347148-59-8]

(R)-(-)-Rolipram

Reference standard for PET tracer [11C]rolipram

[85416-75-7]

Serotonin receptor 1A

WAY 100634

Precursor for PET tracer [carbonyl-11C]WAY-100635

[155204-28-7]

WAY 100635 oxalate

Reference standard Standard for…

[146715-97-8 (free base)]

Serotonin receptor 1B

AZ10419369

Reference standard for PET tracer [11C]AZ10419369

[442548-93-8]

N-Desmethyl-AZ10419369

Precursor for PET tracer [11C]AZ10419369

[947239-77-2]

Serotonin receptor 2A

Altanserine hydrochloride

Reference standard for PET tracer [18F]altanserine

[76330-71-7]

CIMBI-36 hydrochloride

Reference standard for PET tracer [11C]CIMBI-36

[1026511-90-9 (free base)]

MDL 100907

Reference standard for PET tracer [11C]MDL 100907

[139290-65-6]

MDL 105725

Precursor for PET tracer [11C]MDL 100907

[189192-18-5]

N-Boc-Desmethyl-CIMBI-36

Precursor for PET tracer [11C]CIMBI-36

[1404305-57-2]

Nitroaltanserine

Precursor for PET tracer [18F]altanserine

[139418-53-4]

Nitrosetoperone

Precursor for PET tracer [18F]setoperone

[113981-16-1]

Setoperone

Reference standard for PET tracer [11C]setoperone

[86487-64-1]

Serotonin transporter

ADAM

Reference standard for SPECT tracer [123I]ADAM

[305352-10-7]

DASB

Reference standard for PET tracer [11C]DASB

[627490-01-1]

Desmethyl-DASB MASB

Precursor for PET tracer [11C]DASB

[296774-10-2]

Desmethyl-MADAM

Precursor for PET tracer [11C]MADAM

[412015-27-1]

MADAM

Reference standard for PET tracer [11C]MADAM

[411208-45-2]

Tributyltin-ADAM

Precursor for SPECT tracer [123-I]ADAM

[305352-07-2]

Synaptic vesicle glycoprotein 2A

UCB-J

Reference standard for PET tracer [11C]UCB-J

[2242957-52-2 (1604786-87-9)]

Synaptic vesicle glycoprotein 2A (SV2A)

3-Br-UCB-J

Precursor for PET tracer [18F]UCB-J

[NA]

3-Me3Sn-UCB-J

Precursor for PET tracer [18F]UCB-J (* see remarks)

[NA]

BF3-Dm-UCB-J

Precursor for PET tracer [11C]UCB-J

[NA]

Br-Dm-UCB-J

Precursor for PET tracer [11C]UCB-J

[2098041-10-0]

Me3Sn-SDM-2

Precursor for PET tracer [18F]SDM-2

[NA]

Me3Sn-SDM-8 (SynVesT-1 trimethylstannyl precursor)

Precursor for PET tracer [18F]SDM-8 ([18F]-SynVesT-1)

[2289636-79-7]

SDM-8 (SynVesT-1)

Reference standard for PET tracer [18F]SynVesT-1

[2242777-37-1]

Synaptic vesicular amine transporter

(+)-DTBZ (+)-Dihydrotetrabenazine

Reference standard for PET tracer (+)-[11C]DTBZ

[85081-18-1]

(+)-FCD2CD2-DTBZ

Reference standard for PET tracer [18F](+)-FCD2CD2-DTBZ

[NA]

(+)-FE-DTBZ

Reference standard for PET tracer [18F]FE-DTBZ

[937245-41-5]

(+)-9-O-Desmethyl-DTBZ

Precursor for PET tracer [11C](+)-DTBZ

[1065193-59-0]

Translocator protein

Bromo-NNC13-8241

Precursor for SPECT tracer [123I]NNC13-8241

[106937-64-8]

DPA-713

Reference standard for PET tracer [11C]DPA-713

[386297-97-8]

DPA-714

Reference standard for PET tracer [18F]DPA-714

[958233-07-3]

Desmethyl-DPA-713

Precursor for PET tracer [11C]DPA-713

[868072-17-7]

(R)-Desmethyl-PK11195

Precursor for PET tracer [11C](R)-PK11195

[157809-85-3]

(S)-Desmethyl-PK11195

Precursor for PET tracer [11C](S)-PK11195

[157809-86-4]

Desmethylemapunil

Precursor for PET tracer [11C]emapunil

[226953-50-0]

ER176

Reference standard for PET tracer [11C]ER176

[1373887-29-6]

Desmethyl-ER176

Precursor for PET tracer [11C]ER176

[1373887-55-8]

Emapunil AC-5216

Reference standard for PET tracer [11C]emapunil

[226954-04-7]

Me3Sn-NNC13-8241

Precursor for SPECT tracer [123I]NNC13-8241

[178403-07-1]

NNC13-8241

Reference standard for the SPECT tracer [123I]NNC13-8241

[1027662-23-2]

O-Desmethyl-PBR28

Precursor for PET tracer [11C]PBR28

[1005325-42-7]

PBR28

Reference standard for PET tracer [11C]PBR28

[253307-72-1]

(R)-PK11195

Reference standard for PET tracer [11C](R)-PK11195

[85340-56-3]

RO-154513

Reference standard for PET tracer [11C]RO-154513

[91917-65-6]

RO-44 3902

Precursor

[143188-51-6]

Tosylate-DPA-714

Precursor for PET tracer [18F]DPA-714

[958233-17-5]

μ−Opioid receptor

Carfentanil oxalate

Reference standard for PET tracer [11C]carfentanil

[61086-44-0]

Desmethylcarfentanil sodium salt

Precursor for PET tracer [11C]carfentanil

[98598-82-4]

Purity
All of our products stand out due to the high performance demonstrated in applications. The chemical purity is always higher than 95%, usually higher than 98%.
GMP
PharmaSynth follows the GMP production guidelines ensuring a validated manufacturing process that involves qualified personnel and premises that suit the operations to be carried out.
Test labeled
We provide an optimization of labeling, as our regular precursor batches are test labeled in Karolinska Institute. The specific activity is usually higher than 10 000 Ci/mmol in 11C labeling (the best achieved is desmethyl-raclopride 52000 Ci/mmol).
Contact
For more information regarding products and services specifications please contact our chief chemist, Olavi Loog at olavi@pharmasynth.ee or our chief scientific officer Hans Christiaans at hans.christiaans@pharmasynth.ee.