[18F]SynVesT-1 / [18F]SDM-8 / [18F]MNI-1126

The GMP certified precursor for  [18F]SynVesT-1 / [18F]SDM-8 / [18F]MNI-1126 (an [18F]-analog of UCB-J) and the reference standard for SDM-8 / MNI-1126 are available.

R = F


SDM-8 / MNI-1126





R = H








Evaluation of [18F]SynVesT-2 for imaging SV2A in the human brain: kinetics, test-retest reproducibility, and binding specificity.

Cai Z, et al.

JNM (2021), 62 (supplement 1) 44



First-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A.

Naganawa M, et al.

JNM (2021), 62 (4) 561-567

DOI: https://doi.org/10.2967/jnumed.120.249144


PET Imaging of Synaptic Vesicle Protein 2A

Finnema SJ, et al. (2021) 993-1019. PET Imaging of Synaptic Vesicle Protein 2A. In: Dierckx RA, Otte A, de Vries EF, van Waarde A., Lammertsma AA (eds) PET and SPECT of Neurobiological Systems.

DOI: https://doi.org/10.1007/978-3-030-53176-8_29


Cai Z.; Li S. et al.
Synthesis and Preclinical Evaluation of an 18F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT-2
ACS Chem. Neurosci. 2020, 11, 4, 592-603
Publication Date:January 21, 2020

Constantinescu, C.C.; Tresse, C.; Zheng, M. et al.

Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers

Mol Imaging Biol (2019) 21: 509.



Li, S.; Cai, Z.; Wu X.; Holden, H.; Pracitto, R.; Kapinos, M.; Gao, H.; Labaree, D.; Nabulsi, N.; Carson, R.E.; Huang, Y.

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates

ACS Chem. Neurosci. 2019, 10, 3, 1544-1554


Citation: "Radiolabeling of the trimethyltin precursor was more successful compared to several other precursors."